Kate and Gerry McCann have flown to the United States for an interview on the Oprah Winfrey Show to mark two years since their daughter Madeleine's disappearance.
The couple will use their high-profile appearance on the TV programme to release new images of how their missing girl may look now.
They will visit the National Centre for Missing and Exploited Children in Alexandria, Virginia, whose experts have created the computer-aged pictures of Madeleine.
The McCanns flew out of Heathrow Airport with their spokesman, Clarence Mitchell, and Emma Loach, director of a Channel 4 documentary to be shown after the May 3 anniversary